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Photo Lynn Kamerlin

Lynn Kamerlin

Professor

Photo Lynn Kamerlin

On the energetics of ATP hydrolysis in solution

Author

  • Shina C L Kamerlin
  • Arieh Warshel

Summary, in English

ATP hydrolysis is the driving force of many life processes, yet the exact nature of and contributions to the energetics of this reaction are far from being clear. In particular, it is unclear how much of the driving force of this reaction is due to the separation of the already dissociated ADP + P(i) moieties rather than to the chemical event. This fundamental issue is explored here by ab initio calculations that use different solvation models, and it is found that, while the calculations are sensitive to the theoretical approach used, it is quite likely that the dissociation of the charged fragments makes a significant contribution to the energetics of ATP hydrolysis.

Publishing year

2009-11-26

Language

English

Pages

8-15692

Publication/Series

The Journal of Physical Chemistry Part B

Volume

113

Issue

47

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Keywords

  • Adenosine Triphosphate/chemistry
  • Energy Metabolism
  • Hydrolysis
  • Water/chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1520-5207