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Photo Lynn Kamerlin

Lynn Kamerlin

Professor

Photo Lynn Kamerlin

Adventures on the Routes of Protein Evolution-In Memoriam Dan Salah Tawfik (1955-2021)

Author

  • Colin Jackson
  • Agnes Toth-Petroczy
  • Rachel Kolodny
  • Florian Hollfelder
  • Monika Fuxreiter
  • Shina Caroline Lynn Kamerlin
  • Nobuhiko Tokuriki

Summary, in English

Understanding how proteins evolved not only resolves mysteries of the past, but also helps address challenges of the future, particularly those relating to the design and engineering of new protein functions. Here we review the work of Dan S. Tawfik, one of the pioneers of this area, highlighting his seminal contributions in diverse fields such as protein design, high throughput screening, protein stability, fundamental enzyme-catalyzed reactions and promiscuity, that underpin biology and the origins of life. We discuss the influence of his work on how our models of enzyme and protein function have developed and how the main driving forces of molecular evolution were elucidated. The discovery of the rugged routes of evolution has enabled many practical applications, some which are now widely used.

Publishing year

2022-04-15

Language

English

Publication/Series

Journal of Molecular Biology

Volume

434

Issue

7

Document type

Journal article review

Publisher

Elsevier

Keywords

  • Catalysis
  • Directed Molecular Evolution
  • Enzymes
  • Evolution, Molecular
  • High-Throughput Screening Assays
  • Proteins

Status

Published

ISBN/ISSN/Other

  • ISSN: 1089-8638