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Photo Lynn Kamerlin

Lynn Kamerlin

Professor

Photo Lynn Kamerlin

Multiscale modeling of biological functions

Author

  • Shina Caroline Lynn Kamerlin
  • Arieh Warshel

Summary, in English

Recent years have witnessed a tremendous explosion in computational power, which in turn has resulted in great progress in the complexity of the biological and chemical problems that can be addressed by means of all-atom simulations. Despite this, however, our computational time is not infinite, and in fact many of the key problems of the field were resolved long before the existence of the current levels of computational power. This review will start by presenting a brief historical overview of the use of multiscale simulations in biology, and then present some key developments in the field, highlighting several cases where the use of a physically sound simplification is clearly superior to a brute-force approach. Finally, some potential future directions will be discussed.

Publishing year

2011-06-14

Language

English

Pages

11-10401

Publication/Series

Physical chemistry chemical physics : PCCP

Volume

13

Issue

22

Document type

Journal article review

Publisher

Royal Society of Chemistry

Keywords

  • Computer Simulation
  • Models, Biological
  • Quantum Theory
  • Thermodynamics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1463-9084