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Photo Lynn Kamerlin

Lynn Kamerlin

Professor

Photo Lynn Kamerlin

Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation

Author

  • Ana Rita Calixto
  • Cátia Moreira
  • Shina Caroline Lynn Kamerlin

Summary, in English

GTP hydrolysis is central to biology, being involved in regulating a wide range of cellular processes. However, the mechanisms by which GTPases hydrolyze this critical reaction remain controversial, with multiple mechanistic possibilities having been proposed based on analysis of experimental and computational data. In this mini-review, we discuss advances in our understanding of biological GTP hydrolysis based on recent computational studies and argue in favor of solvent-assisted hydrolysis as a conserved mechanism among GTPases. A concrete understanding of the fundamental mechanisms by which these enzymes facilitate GTP hydrolysis will have significant impact both for drug discovery efforts and for unraveling the role of oncogenic mutations.

Publishing year

2020-03-10

Language

English

Pages

4380-4385

Publication/Series

ACS Omega

Volume

5

Issue

9

Document type

Journal article review

Publisher

The American Chemical Society (ACS)

Status

Published

ISBN/ISSN/Other

  • ISSN: 2470-1343