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Photo Lynn Kamerlin

Lynn Kamerlin

Professor

Photo Lynn Kamerlin

CADEE : Computer-Aided Directed Evolution of Enzymes

Author

  • Beat Anton Amrein
  • Fabian Steffen-Munsberg
  • Ireneusz Szeler
  • Miha Purg
  • Yashraj Kulkarni
  • Shina Caroline Lynn Kamerlin

Summary, in English

The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE) is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of the application of CADEE to a real biological system is also presented in order to illustrate the CADEE workflow.

Publishing year

2017-01-01

Language

English

Pages

50-64

Publication/Series

IUCrJ

Volume

4

Issue

Pt 1

Document type

Journal article

Publisher

International Union of Crystallography

Status

Published

ISBN/ISSN/Other

  • ISSN: 2052-2525