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Photo Mikael Lund

Mikael Lund

Professor

Photo Mikael Lund

Charge-Induced Patchy Attractions between Proteins

Author

  • Weimin Li
  • Björn Persson
  • Maxim Morin
  • Manja Behrens
  • Mikael Lund
  • Malin Zackrisson Oskolkova

Summary, in English

Static light scattering (SLS) combined with structure-based Monte Carlo (MC) simulations provide new insights into mechanisms behind anisotropic, attractive protein interactions. A nonmonotonic behavior of the osmotic second virial coefficient as a function of ionic strength is here shown to originate from a few charged amino acids forming an electrostatic attractive patch, highly directional and complementary. Together with Coulombic repulsion, this attractive patch results in two counteracting electrostatic contributions to the interaction free energy which, by operating over different length scales, is manifested in a subtle, salt-induced minimum in the second virial coefficient as observed in both experiment and simulations.

Department/s

  • Physical Chemistry
  • Computational Chemistry

Publishing year

2015

Language

English

Pages

503-508

Publication/Series

The Journal of Physical Chemistry Part B

Volume

119

Issue

2

Document type

Article

Publisher

The American Chemical Society (ACS)

Topic

  • Physical Chemistry (including Surface- and Colloid Chemistry)
  • Theoretical Chemistry (including Computational Chemistry)

Status

Published

ISBN/ISSN/Other

  • ISSN: 1520-5207