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Photo Mikael Lund

Mikael Lund

Professor

Photo Mikael Lund

Electrostatic Chameleons in Biological Systems.

Author

  • Mikael Lund

Summary, in English

Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.

Department/s

  • Computational Chemistry
  • eSSENCE: The e-Science Collaboration

Publishing year

2010

Language

English

Pages

17337-17339

Publication/Series

Journal of the American Chemical Society

Volume

132

Issue

49

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Theoretical Chemistry (including Computational Chemistry)

Status

Published

ISBN/ISSN/Other

  • ISSN: 1520-5126