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Photo Mikael Lund

Mikael Lund

Professor

Photo Mikael Lund

Enhanced protein adsorption due to charge regulation

Author

  • Mikael Lund
  • Torbjörn Åkesson
  • Bo Jönsson

Summary, in English

When a protein molecule approaches a charged surface, its protonation state can undergo dramatic changes due to the imposed electric potential. This has a large impact on adsorption strengths that may be enhanced by several kT. Using mesoscopic simulation techniques as well as analytical theories, we have investigated this regulation mechanism and demonstrate how it is influenced by salt concentration and solution pH. Using hisactophilin as a test case, we show how the binding to a lipid membrane is governed by small changes in pH and that this is intimately coupled to the charge regulation mechanism.

Department/s

  • Computational Chemistry

Publishing year

2005

Language

English

Pages

8385-8388

Publication/Series

Langmuir

Volume

21

Issue

18

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Theoretical Chemistry (including Computational Chemistry)

Status

Published

ISBN/ISSN/Other

  • ISSN: 0743-7463