2022-01-25

New article published in Journal of Physical Chemistry B, January 2022: Self-Diffusive Properties of the Intrinsically Disordered Protein Histatin 5 and the Impact of Crowding Thereon: A Combined Neutron Spectroscopy and Molecular Dynamics Simulation Study, by E. Fagerberg, S. Lenton, T. Nylander, T. Seydel, and M. Skepö. Intrinsically disordered proteins (IDPs) are proteins with a fluctuating structure, why a specific structure cannot be assigned to them. In this study, we are investigating the diffusive properties of the salivary IDP Histatin 5, as a function of increasing protein concentration. For this purpose, we are utilizing quasi-elastic neutron scattering together with molecular dynamics. A significant decrease in diffusion with increasing protein concentration is found, while simulations show semi-quantitative agreement with experiment. The article is published open access and can be reached here: DOI: 10.1021/acs.jpcb.1c08976